Omega-3 Fatty Acid Supplementation and Cognitive Function in Alzheimer’s Risk
Docosahexaenoic acid (DHA), an omega-3 fatty acid found in oily fish, is thought to improve cognitive function by supporting connections between brain cells. However, previous studies have yielded mixed results regarding its effectiveness as a dietary supplement against dementia.
Clinical Trial Findings
A research team at the USC School of Medicine recently published the findings of a two-year clinical trial involving older adults at increased risk of developing Alzheimer’s disease. The study found that while high-dose DHA supplements did indeed reach the brain, they did not significantly improve memory, cognitive function, or slow brain atrophy.
Methodology
The study involved 365 individuals between the ages of 55 and 80 who rarely consumed fish. Participants were randomly assigned to receive either a daily supplement containing 2,000 mg of DHA or a placebo for 24 months. DHA levels in the cerebrospinal fluid were measured to assess brain absorption.
Results
After 24 months, neither the DHA nor the placebo group showed significant changes in memory performance or hippocampal volume. These findings suggest that fish oil supplements may not be effective as a preventive measure against Alzheimer’s disease.
