Doctors thought this kidney drug helped some patients. It may help millions more.
Details
– George Institute for Global Health
– A trio of major studies found that finerenone may protect the kidneys and heart in far more people than previously thought. The drug significantly slowed kidney disease progression and reduced the risks of kidney failure, heart failure, cardiovascular death, and overall mortality. Researchers saw benefits not only in patients with diabetes but also in those with non-diabetic kidney disease, a group with limited treatment options.
Large international studies have found that the kidney disease drug finerenone may benefit far more patients than current treatment guidelines recommend.
Researchers reported that the medication helps protect kidney function, lowers the risk of cardiovascular complications, and improves survival in people with chronic kidney disease (CKD). The benefits were seen not only in patients with diabetes but also in those with non-diabetic CKD and certain forms of glomerular disease.
The findings were presented at the European Renal Association Congress in Glasgow, United Kingdom, and were simultaneously published in three leading medical journals: The Lancet, The New England Journal of Medicine, and JAMA. Achieving publication in all three journals at the same time is an uncommon milestone in clinical research.
Finerenone Shows Promise Beyond Diabetes
Finerenone is a non-steroidal mineralocorticoid receptor antagonist currently approved to treat CKD associated with type 2 diabetes. Researchers have become increasingly interested in whether the drug could help a broader range of kidney disease patients because excessive activation of the mineralocorticoid receptor contributes to inflammation and scarring in many kidney disorders.
– Kyle J Foreman, Neal Marquez, Andrew Dolgert, Kai Fukutaki, Nancy Fullman, Madeline McGaughey, Martin A Pletcher, Amanda E Smith, Kendrick Tang, Chun-Wei Yuan, Jonathan C Brown, Joseph Friedman, Jiawei He, Kyle R Heuton, Mollie Holmberg, Disha J Patel, Patrick Reidy, Austin Carter, Kelly Cercy, Abigail Chapin, Dirk Douwes-Schultz, Tahvi Frank, Falko Goettsch, Patrick Y Liu, Vishnu Nandakumar, Marissa B Reitsma, Vince Reuter, Nafis Sadat, Reed J D Sorensen, Vinay Srinivasan, Rachel L Updike, Hunter York, Alan D Lopez, Rafael Lozano, Stephen S Lim, Ali H Mokdad, Stein Emil Vollset, Christopher
Stay informed with the latest news on Wararka.so — your trusted source for Somalia and world news.
